Abstract
Nonrandomized studies are often conservative in estimating absolute risks of harms. It would be useful to compare and scrutinize the evidence on harms obtained from both randomized and nonrandomized studies.
Keywords
Randomized controlled trialMedicineRelative riskAbsolute risk reductionPsychological interventionMEDLINENumber needed to treatNumber needed to harmIntensive care medicineInternal medicineConfidence intervalPsychiatry
Affiliated Institutions
Related Publications
Diabetes Prevention and Treatment Strategies
OBJECTIVE Effective interventions to prevent, delay, or remit diabetes are currently available. However, their impact on the prevalence of diabetes at the population level is un...
Better Reporting of Harms in Randomized Trials: An Extension of the CONSORT Statement
In response to overwhelming evidence and the consequences of poor-quality reporting of randomized, controlled trials (RCTs), many medical journals and editorial groups have now ...
Update and Next Steps for Real-World Translation of Interventions for Type 2 Diabetes Prevention: Reflections From a Diabetes Care Editors’ Expert Forum
The International Diabetes Federation estimates that 415 million adults worldwide now have diabetes and 318 million have impaired glucose tolerance. These numbers are expected t...
Effect of Antihypertensive Treatment in Patients Having Already Suffered From Stroke
Background and Purpose Drug treatment of high blood pressure has been shown to reduce the associated cardiovascular risk. Stroke represents the type of event more strongly linke...
Measuring the Psychological Outcomes of Falling: A Systematic Review
The objectives were to identify fall‐related psychological outcome measures and to undertake a systematic quality assessment of their key measurement properties. A Cochrane revi...
Publication Info
- Year
- 2006
- Type
- article
- Volume
- 174
- Issue
- 5
- Pages
- 635-641
- Citations
- 230
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
230
OpenAlex
Cite This
Panagiotis N. Papanikolaou
(2006).
Comparison of evidence on harms of medical interventions in randomized and nonrandomized studies.
Canadian Medical Association Journal
, 174
(5)
, 635-641.
https://doi.org/10.1503/cmaj.050873
Identifiers
- DOI
- 10.1503/cmaj.050873