Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

Keywords

Bipolar disorderGenome-wide association studyAnkyrinBiologyGenetic associationGeneticsCalcium channelProtein subunitBipolar II disorderG alpha subunitGeneSingle-nucleotide polymorphismNeuroscienceInternal medicineGenotypeMedicineCalciumCognition

Affiliated Institutions

Related Publications

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

Paul R. Burton , David Clayton , Lon R. Cardon +97 more

There is increasing evidence that genome-wide association (GWA) studies represent a powerful approach to the identification of genes involved in common human diseases. We descri...

2007 Nature 9552 citations

Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels

Richa Saxena , Benjamin F. Voight , Valeriya Lyssenko +64 more

New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (...

2007 Science 2875 citations

A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants

Laura J. Scott , Karen L. Mohlke , Lori L. Bonnycastle +38 more

Identifying the genetic variants that increase the risk of type 2 diabetes (T2D) in humans has been a formidable challenge. Adopting a genome-wide association strategy, we genot...

2007 Science 2757 citations

The Genotype-Tissue Expression (GTEx) project.

John T. Lonsdale , Jeffrey Thomas , Mike Salvatore +97 more

Genome-wide association studies have identified thousands of loci for common diseases, but, for the majority of these, the mechanisms underlying disease susceptibility remain un...

2013 PubMed 9436 citations

Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes

Eleftheria Zeggini , Michael N. Weedon , Cecilia M. Lindgren +23 more

The molecular mechanisms involved in the development of type 2 diabetes are poorly understood. Starting from genome-wide genotype data for 1924 diabetic cases and 2938 populatio...

2007 Science 2195 citations

Publication Info

Year: 2008
Type: article
Volume: 40
Issue: 9
Pages: 1056-1058
Citations: 1236
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1236

OpenAlex

Cite This

APA Style

                            
                                
                                    Manuel A. R. Ferreira, 
                                
                                    Michael O’Donovan, 
                                
                                    Yan Meng
                                
                                et al.
                            
                            (2008). 
                            Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. 
                            Nature Genetics
                            , 40
                            (9)
                            , 1056-1058.
                            https://doi.org/10.1038/ng.209
                        

Identifiers

DOI: 10.1038/ng.209