Abstract
Abstract Partially purified, concentrated interleukin 2 (IL2) was injected i.v. into normal and T cell‐depleted mice. At various times after injection IL 2 was determined in the sera of these mice. An interference with the test by a potential inhibitor of IL 2 in the serum was excluded. IL 2 was cleared equally rapidly, with a half‐life of 3 min, from the blood of both groups of mice. It is concluded that IL 2 is a short‐range mediator under physiological conditions, and that clearance was not due to adsorption to T cells.
Keywords
ClearanceBiologyImmunologyInterleukin 2InterleukinMediatorEndocrinologyInternal medicineCytokineMedicine
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Publication Info
- Year
- 1982
- Type
- article
- Volume
- 12
- Issue
- 11
- Pages
- 983-985
- Citations
- 48
- Access
- Closed
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Cite This
Peter F. Mühlradt,
H.G. Opitz
(1982).
Clearance of interleukin 2 from the blood of normal and T cell‐depleted mice.
European Journal of Immunology
, 12
(11)
, 983-985.
https://doi.org/10.1002/eji.1830121117
Identifiers
- DOI
- 10.1002/eji.1830121117