Abstract
Guidelines for design, validation and operation of clean-in-place systems for industrial fermentation plant are presented. Design of vessels, surface finishes, materials of construction, types and locations of valves are some of the considerations addressed. Requisite levels of turbulence for cleaning of pipes and vessels are discussed as well as typical cleaning sequences. Recommendations for validation of cleaning are presented and the significance of design of cleaning systems in ensuring satisfactory validation is pointed out. To the extent possible, validation of cleaning should be carried out with real process soil or soil closely simulating actual fermentation broths.
Keywords
Process engineeringProcess validationBioreactorEnvironmental scienceProcess (computing)Computer scienceBiochemical engineeringEngineeringVerification and validationChemistryOperations management
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Publication Info
- Year
- 1994
- Type
- article
- Volume
- 13
- Issue
- 4
- Pages
- 201-207
- Citations
- 88
- Access
- Closed
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Cite This
Yusuf Chisti,
Murray Moo‐Young
(1994).
Clean-in-place systems for industrial bioreactors: Design, validation and operation.
Journal of Industrial Microbiology & Biotechnology
, 13
(4)
, 201-207.
https://doi.org/10.1007/bf01569748
Identifiers
- DOI
- 10.1007/bf01569748