Abstract

Chemotherapy significantly improves survival in comparison to best supportive care. In addition, combination chemotherapy improves survival compared to single-agent 5-FU. All patients should be tested for their HER-2 status and trastuzumab should be added to a standard fluoropyrimidine/cisplatin regimen in patients with HER-2 positive tumours. Two and three-drug regimens including 5-FU, cisplatin, with or without an anthracycline, as well as irinotecan or docetaxel-containing regimens are reasonable treatment options for HER-2 negative patients.

Keywords

MedicineChemotherapyHazard ratioMeta-analysisInternal medicineCancerOncologyConfidence intervalIntensive care medicineSurgery

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Publication Info

Year
2010
Type
review
Issue
3
Pages
CD004064-CD004064
Citations
470
Access
Closed

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Dorothea Wagner, Susanne Unverzagt, Wilfried Grothe et al. (2010). Chemotherapy for advanced gastric cancer. Cochrane Database of Systematic Reviews (3) , CD004064-CD004064. https://doi.org/10.1002/14651858.cd004064.pub3

Identifiers

DOI
10.1002/14651858.cd004064.pub3