Abstract
An adequate virologic response after initiation of antiretroviral therapy seems to require a decrease in plasma HIV RNA level of at least 0.5 log10 copies/mL that is sustained for at least 6 months. The independent relation between plasma HIV RNA level and CD4+ lymphocyte count over time and clinical outcome suggests that the measurement of plasma HIV RNA level, in addition to the CD4+ lymphocyte count, has a role in guiding the management of antiretroviral therapy.
Keywords
MedicineInternal medicinePlaceboZidovudineLymphocyteRandomizationImmunologyLentivirusSidaRandomized controlled trialViral loadClinical trialViral diseaseHuman immunodeficiency virus (HIV)Pathology
Related Publications
Update on prevention, diagnosis, and treatment of chronic hepatitis B
Potential conflict of interest: Dr. Hwang received grants from Merck and Gilead. Dr. Chang advises Arbutus. Dr. Lok received grants from Gilead and Bristol‐Myers Squibb. Dr. Jon...
Non‐alcoholic steatohepatitis: Definitions and pathogenesis
The term 'non-alcoholic steatohepatitis' or NASH was first used by Ludwig et al. in 1980 to describe 'the pathological and clinical features of non-alcoholic disease of the live...
Publication Info
- Year
- 1997
- Type
- article
- Volume
- 126
- Issue
- 12
- Pages
- 939-945
- Citations
- 262
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
262
OpenAlex
Cite This
William A. O’Brien
(1997).
Changes in Plasma HIV RNA Levels and CD4+ Lymphocyte Counts Predict Both Response to Antiretroviral Therapy and Therapeutic Failure.
Annals of Internal Medicine
, 126
(12)
, 939-945.
https://doi.org/10.7326/0003-4819-126-12-199706150-00002
Identifiers
- DOI
- 10.7326/0003-4819-126-12-199706150-00002