Abstract
TWO BASIC forms of hypoxic brain damage make their appearance in the fetus and newborn. The lesions, located in the cerebrum, distributed through the cortical and deep structures, are not of random occurrence. The cerebral damage evolves in precise patterns; the location of lesions is governed by the gestational age of the fetus or neonate at the time of the hypoxic event. This temporal factor is of significance not only in determining the anatomic pattern of the cerebral damage, but correspondingly, has a direct bearing on the ultimate form of the neurologic defect in infants who survive. Accordingly, the findings here offer an organic basis for correlating the occurrence of gestational complications, particularly prematurity, with the presence clinically of cerebral palsy, mental retardation, and other nervous system defects in infants who survive. Traditionally the occurrence of hypoxic damage in the neonatal brain has been minimized.
Keywords
Cerebral palsyBrain damageCerebrumFetusMedicineGestational ageCentral nervous systemHypoxia (environmental)PregnancyBiologyInternal medicineChemistryOxygen
Related Publications
Care of the High-Risk Neonate
1. Antenatal and Intrapartum Care of the High-Risk Infant 2. Resuscitation of the Newborn Infant 3. Recognition, Stabilization and Transport of the High-Risk Newborn 4. Classifi...
Pathogenesis of intraventricular haemorrhage in newborn infants
The ventricular CSF of a group of preterm infants dying in the newborn period contained a large excess of protein which appeared to be a plasma filtrate. This excess was found w...
Subependymal and Intraventricular Hemorrhage in Neonates
Computed tomography was used to evaluate subependymal and intraventricular hemorrhage in 11 formalin-fixed brains obtained at autopsy from newborn infants from a population with...
Subependymal and intraventricular hemorrhages in the newborn.
The pathogenesis of intraventricular hemorrhage in the newborn includes that of subependymal hemorrhage (SEH), the single most common pathologic alteration seen in the brains of...
Subependymal Cerebral Hemorrhage in Infancy
SUBEPENDYMAL cerebral hemorrhage with intraventricular inundation, occurring almost exclusively in premature infants,<sup>1-9</sup>has been encountered in approximately 15% of p...
Publication Info
- Year
- 1969
- Type
- article
- Volume
- 20
- Issue
- 1
- Pages
- 35-35
- Citations
- 58
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
58
OpenAlex
Cite This
Abraham Towbin
(1969).
Cerebral Hypoxic Damage in Fetus and Newborn.
Archives of Neurology
, 20
(1)
, 35-35.
https://doi.org/10.1001/archneur.1969.00480070045005
Identifiers
- DOI
- 10.1001/archneur.1969.00480070045005