Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

Amit Zeisel; Ana B. Muñoz‐Manchado; Simone Codeluppi; Peter Lönnerberg; Gioele La Manno; Anna Juréus; Sueli Marques; Hermany Munguba; Liqun He; Christer Betsholtz; Charlotte Rolny; Gonçalo Castelo‐Branco; Jens Hjerling‐Leffler; Sten Linnarsson

doi:10.1126/science.aaa1934

Abstract

Cellular diversity in the brain revealed The mammalian brain has an extraordinarily large number of cells. Although there are quite a few different cell types, many cells in any one category tend to look alike. Zeisel et al. analyzed the transcriptomes of mouse brain cells to reveal more than meets the eye. Interneurons of similar type were found in dissimilar regions of the brain. Oligodendrocytes that seemed to be all of one class were differentiated by their molecular signatures into a half-dozen classes. Microglia associated with blood vessels were distinguished from look-alike perivascular macrophages. Thus, the complex microanatomy of the brain can be revealed by the RNAs expressed in its cells. Science , this issue p. 1138

Keywords

Cell typeBiologyNeuroscienceInterneuronHippocampal formationCerebral cortexSomatosensory systemCortex (anatomy)HippocampusCellTranscription factorCell biologyGeneGeneticsInhibitory postsynaptic potential

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Publication Info

Year: 2015
Type: article
Volume: 347
Issue: 6226
Pages: 1138-1142
Citations: 3299
Access: Closed

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APA Style

                            
                                
                                    Amit Zeisel, 
                                
                                    Ana B. Muñoz‐Manchado, 
                                
                                    Simone Codeluppi
                                
                                et al.
                            
                            (2015). 
                            Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq. 
                            Science
                            , 347
                            (6226)
                            , 1138-1142.
                            https://doi.org/10.1126/science.aaa1934
                        

Identifiers

DOI: 10.1126/science.aaa1934