Cell Membrane Tracker Based on Restriction of Intramolecular Rotation

Abstract

The fluorescence of tetraphenylethylene (TPE), an archetypal luminogen, is induced by restriction of intramolecular rotation (RIR). TPE was grafted with palmitic acid (PA) onto a hydrophilic peptide to yield a cell membrane tracker named TR4. TR4 was incorporated into liposomes, where it showed significant RIR characteristics. When cells were incubated with TR4, cytoplasmic membranes were specifically labeled. TR4 shows excellent photostability and low cytotoxicity.

Keywords

TetraphenylethyleneIntramolecular forceMembraneMaterials scienceCytoplasmCell membraneFluorescenceBiophysicsPalmitic acidCytotoxicityYield (engineering)IntracellularLiposomeCellCrystallographyStereochemistryIn vitroBiochemistryChemistryBiologyNanotechnologyOpticsAggregation-induced emissionPhysicsFatty acid

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Publication Info

Year: 2014
Type: article
Volume: 6
Issue: 12
Pages: 8971-8975
Citations: 108
Access: Closed

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APA Style

                            
                                
                                    Chunqiu Zhang, 
                                
                                    Shubin Jin, 
                                
                                    Keni Yang
                                
                                et al.
                            
                            (2014). 
                            Cell Membrane Tracker Based on Restriction of Intramolecular Rotation. 
                            ACS Applied Materials & Interfaces
                            , 6
                            (12)
                            , 8971-8975.
                            https://doi.org/10.1021/am5025897
                        

Identifiers

DOI: 10.1021/am5025897