Cell entry mechanisms of SARS-CoV-2 | RDL Research Database

Abstract

Significance A key to curbing SARS-CoV-2 is to understand how it enters cells. SARS-CoV-2 and SARS-CoV both use human ACE2 as entry receptor and human proteases as entry activators. Using biochemical and pseudovirus entry assays and SARS-CoV as a comparison, we have identified key cell entry mechanisms of SARS-CoV-2 that potentially contribute to the immune evasion, cell infectivity, and wide spread of the virus. This study also clarifies conflicting reports from recent studies on cell entry of SARS-CoV-2. Finally, by highlighting the potency and the evasiveness of SARS-CoV-2, the study provides insight into intervention strategies that target its cell entry mechanisms.

Keywords

FurinProteasesViral entryBiologyReceptorCoronavirusCell biologyVirologyProteaseCellVirusCoronavirus disease 2019 (COVID-19)EnzymeBiochemistryViral replicationMedicineDisease

Affiliated Institutions

University of Minnesota US

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Publication Info

Year: 2020
Type: article
Volume: 117
Issue: 21
Pages: 11727-11734
Citations: 3375
Access: Closed

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APA Style

                            
                                
                                    Jian Shang, 
                                
                                    Yushun Wan, 
                                
                                    Chuming Luo
                                
                                et al.
                            
                            (2020). 
                            Cell entry mechanisms of SARS-CoV-2. 
                            Proceedings of the National Academy of Sciences
                            , 117
                            (21)
                            , 11727-11734.
                            https://doi.org/10.1073/pnas.2003138117
                        

Identifiers

DOI: 10.1073/pnas.2003138117