Abstract
There are two major trials of aspirin in acute ischaemic stroke. Taken together, CAST and the similarly large IST show reliably that aspirin started early in hospital produces a small but definite net benefit, with about 9 (SD 3) fewer deaths or non-fatal strokes per 1000 in the first few weeks (2p = 0.001), and with 13 (5) fewer dead or dependent per 1000 after some weeks or months of follow-up (2p < 0.01).
Keywords
AspirinMedicinePlaceboStroke (engine)Myocardial infarctionRandomized controlled trialAcute strokeInternal medicineIschaemic strokeClinical trialSurgeryIschemiaTissue plasminogen activator
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Publication Info
- Year
- 1997
- Type
- article
- Volume
- 349
- Issue
- 9066
- Pages
- 1641-9
- Citations
- 253
- Access
- Closed
External Links
Citation Metrics
253
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Cite This
(1997).
CAST: randomised placebo-controlled trial of early aspirin use in 20,000 patients with acute ischaemic stroke. CAST (Chinese Acute Stroke Trial) Collaborative Group..
PubMed
, 349
(9066)
, 1641-9.