Abstract
REVIEW Apoptosis, an evolutionarily conserved form of cell suicide, requires specialized machinery. The central component of this machinery is a proteolytic system involving a family of proteases called caspases. These enzymes participate in a cascade that is triggered in response to proapoptotic signals and culminates in cleavage of a set of proteins, resulting in disassembly of the cell. Understanding caspase regulation is intimately linked to the ability to rationally manipulate apoptosis for therapeutic gain.
Keywords
ProteasesCaspaseCell biologyCleavage (geology)ApoptosisBiologyCaspase 2Proteolytic enzymesIntrinsic apoptosisProgrammed cell deathEnzymeGeneticsBiochemistry
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Publication Info
- Year
- 1998
- Type
- review
- Volume
- 281
- Issue
- 5381
- Pages
- 1312-1316
- Citations
- 6894
- Access
- Closed
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Cite This
Nancy A. Thornberry,
Yuri Lazebnik
(1998).
Caspases: Enemies Within.
Science
, 281
(5381)
, 1312-1316.
https://doi.org/10.1126/science.281.5381.1312
Identifiers
- DOI
- 10.1126/science.281.5381.1312