Abstract
In vivo selection of phage display libraries was used to isolate peptides that home specifically to tumor blood vessels. When coupled to the anticancer drug doxorubicin, two of these peptides—one containing an α v integrin–binding Arg-Gly-Asp motif and the other an Asn-Gly-Arg motif—enhanced the efficacy of the drug against human breast cancer xenografts in nude mice and also reduced its toxicity. These results indicate that it may be possible to develop targeted chemotherapy strategies that are based on selective expression of receptors in tumor vasculature.
Keywords
CancerDrugDrug deliveryMedicineCancer drugsCancer researchPharmacologyInternal medicineChemistry
MeSH Terms
AnimalsAntigensCDAntineoplastic AgentsBacteriophagesCoronary VesselsDoxorubicinDrug CarriersHeartHumansIntegrin alphaVIntegrinsLiverMiceMiceNudeNeoplasm TransplantationNeoplasmsExperimentalOligopeptidesPeptide LibraryRandom AllocationTransplantationHeterologousTumor CellsCultured
Affiliated Institutions
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Phagocytosis by monocytes or neutrophils can be enhanced by interaction with several proteins or synthetic peptides containing the Arg-Gly-Asp sequence. Recently we showed that ...
Publication Info
- Year
- 1998
- Type
- article
- Volume
- 279
- Issue
- 5349
- Pages
- 377-380
- Citations
- 2044
- Access
- Closed
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Cite This
Wadih Arap,
Renata Pasqualini,
Erkki Ruoslahti
(1998).
Cancer Treatment by Targeted Drug Delivery to Tumor Vasculature in a Mouse Model.
Science
, 279
(5349)
, 377-380.
https://doi.org/10.1126/science.279.5349.377
Identifiers
- DOI
- 10.1126/science.279.5349.377
- PMID
- 9430587