Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties

Abstract

Caffeic acid phenethyl ester, an active component of propolis extract, inhibits 5‐lipoxygenase in the micromolar concentration range. The inhibition is of an uncompetitive type, i.e. the inhibitor binds to the enzyme‐substrate complex but not to the free enzyme. Caffeic acid phenethyl ester also exhibits antioxidant properties. At a concentration of 10 μM, it completely blocks production of reactive oxygen species in human neutrophils and the xanthine/xanthine oxidase system.

Keywords

Caffeic acid phenethyl esterCaffeic acidXanthine oxidaseChemistryPropolisBiochemistryAntioxidantLipoxygenaseEnzymeUncompetitive inhibitorSubstrate (aquarium)Xanthine oxidase inhibitorNon-competitive inhibitionBiologyFood science

Affiliated Institutions

Lomonosov Moscow State University RU

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Publication Info

Year: 1993
Type: article
Volume: 329
Issue: 1-2
Pages: 21-24
Citations: 507
Access: Closed

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APA Style

                            
                                
                                    Galina F. Sud’ina, 
                                
                                    Olga K. Mirzoeva, 
                                
                                    Marina A. Pushkareva
                                
                                et al.
                            
                            (1993). 
                            Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties. 
                            FEBS Letters
                            , 329
                            (1-2)
                            , 21-24.
                            https://doi.org/10.1016/0014-5793(93)80184-v
                        

Identifiers

DOI: 10.1016/0014-5793(93)80184-v