Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

Timothy P. Sheahan , Amy Sims , Rachel L. Graham , Timothy P. Sheahan , Amy Sims , Rachel L. Graham , Vineet D. Menachery , Lisa E. Gralinski , James Brett Case , Sarah R. Leist , Krzysztof Pyrć , Joy Y. Feng , Iva Trantcheva , Roy Bannister , Yeojin Park , Darius Babusis , Michael O. Clarke , Richard L. Mackman , Jamie E. Spahn , Christopher A. Palmiotti , Dustin S. Siegel , Adrian S. Ray , Tomáš Cihlář , Robert Jordan , Mark R. Denison , Ralph S. Baric
2017 Science Translational Medicine 1,606 citations

Abstract

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses in vitro and in vivo.

Keywords

VirologyCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakCoronavirusZoonotic diseaseBroad spectrumBiologyMicrobiologyIn vitroMedicineOutbreakChemistryGeneticsInfectious disease (medical specialty)Disease

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Year
2017
Type
article
Volume
9
Issue
396
Citations
1606
Access
Closed

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Timothy P. Sheahan, Amy Sims, Rachel L. Graham et al. (2017). Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses. Science Translational Medicine , 9 (396) . https://doi.org/10.1126/scitranslmed.aal3653

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DOI
10.1126/scitranslmed.aal3653