Abstract
Concern has arisen about the magnitude, impact, and interpretation of preanalytical as well as analytical sources of variation on reported results of lipid measurements of an individual. Preanalytical sources of variation from behavioral, clinical, and sampling sources constitute about 60% of the total variation in a reported lipid measurement of an individual. A technique is presented to allow physicians to qualitatively estimate the intraindividual biological variation of a patient from the results of two or more specimens reported from a standardized laboratory and to determine whether additional specimens are needed to meet the National Cholesterol Education Program recommendation that the intraindividual serum total cholesterol coefficient of variation not exceed 5.0. A National Reference Method Network has been established to help solve analytical problems.
Keywords
MedicineCoefficient of variationVariation (astronomy)Coronary heart diseaseStatisticsReliability (semiconductor)Internal medicineMathematics
Affiliated Institutions
Related Publications
Prevalence of diabetes, pre-diabetes and associated risk factors: second National Diabetes Survey of Pakistan (NDSP), 2016–2017
Objective The second National Diabetes Survey of Pakistan (second NDSP) was planned to ascertain the updated prevalence of diabetes, pre-diabetes and associated risk factors at ...
The Clinical Utility of a Six‐Minute Walk Test in Peripheral Arterial Occlusive Disease Patients
OBJECTIVES: To determine the test‐retest reliability of the distance covered and the steps taken to complete a 6‐minute walk test by peripheral arterial occlusive disease (PAOD)...
Decline in Cardiovascular Mortality
If the control of infectious diseases was the public health success story of the first half of the 20th century, then the decline in mortality from coronary heart disease and st...
Nonalcoholic Fatty Liver, Steatohepatitis, and the Metabolic Syndrome
Nonalcoholic fatty liver disease (NAFLD) has been associated with the insulin–resistance syndrome, at present defined as the metabolic syndrome, whose limits were recently set. ...
Multiple Rare Alleles Contribute to Low Plasma Levels of HDL Cholesterol
Heritable variation in complex traits is generally considered to be conferred by common DNA sequence polymorphisms. We tested whether rare DNA sequence variants collectively con...
Publication Info
- Year
- 1992
- Type
- article
- Volume
- 267
- Issue
- 12
- Pages
- 1652-1652
- Citations
- 141
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
141
OpenAlex
Cite This
Gerald R. Cooper
(1992).
Blood Lipid Measurements.
JAMA
, 267
(12)
, 1652-1652.
https://doi.org/10.1001/jama.1992.03480120090039
Identifiers
- DOI
- 10.1001/jama.1992.03480120090039