Abstract

The biological half-time of cadmium in the blood of previously exposed workers was estimated after the cessation of exposure. Five men were followed for a period of 10 to 13 years. One-compartment and two-compartment exponential elimination models were used to describe the decrease in blood cadmium levels over time. The best fit to the observed data was obtained with a two-compartment model. The half-times estimated from this model ranged from 75 to 128 d for the fast component and from 7.4 to 16.0 years for the slow component. The results confirm that there is a very long whole-body biological half-time for cadmium, and the estimated half-times are similar to those obtained with different methods.

Keywords

CadmiumCompartment (ship)Internal doseBlood componentPhysiologyBlood concentrationComponent (thermodynamics)ToxicokineticsToxicologyMedicineChemistryInternal medicineBiologyPharmacokineticsEmergency medicineRadiochemistryPhysics

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Publication Info

Year
1983
Type
article
Volume
9
Issue
4
Pages
327-331
Citations
204
Access
Closed

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Lars Järup, Artur Rogenfelt, C G Elinder et al. (1983). Biological half-time of cadmium in the blood of workers after cessation of exposure.. Scandinavian Journal of Work Environment & Health , 9 (4) , 327-331. https://doi.org/10.5271/sjweh.2404

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DOI
10.5271/sjweh.2404