Abstract
Neutrophils, the most common inflammatory leukocytes, have the most limited life span of all blood cells. After they undergo apoptosis, they are recognized and engulfed by macrophages. bcl-2, a proto-oncogene rearranged and deregulated in B cell lymphomas bearing the t(14;18) translocation, is known to inhibit programmed death. bcl-2 expression is localized in early myeloid cells of the bone marrow but is absent in mature neutrophils. Transgenic mice that expressed bcl-2 in mature neutrophils showed that bcl-2 blocked neutrophil apoptosis. Despite this, homeostasis of neutrophil population is essentially unaffected. In fact, macrophage uptake of neutrophils expressing bcl-2 still occurred. This transgenic model indicates that the mechanism that triggers phagocytosis of aging neutrophils operates independently of the process of apoptosis regulated by bcl-2.
Keywords
PhagocytosisApoptosisBiologyCell biologyMacrophageProgrammed cell deathBone marrowMyeloidPopulationGranulocyteImmunologyIn vitroMedicineGenetics
Affiliated Institutions
Related Publications
Involvement of Caspases in Neutrophil Apoptosis: Regulation by Reactive Oxygen Species
Abstract Human neutrophils have a short half-life and are believed to die by apoptosis or programmed cell death both in vivo and in vitro. We found that caspases are activated i...
Hematopoietic Stem Cells Need Two Signals to Prevent Apoptosis; Bcl-2 Can Provide One of These, Kitl/C-KIT Signaling the Other
Growth factors can cause cells to proliferate, differentiate, survive, or die. Distinguishing between these responses is difficult in multicellular, multiparameter systems. Yet ...
Systemic Overexpression of BCL-2 in the Hematopoietic System Protects Transgenic Mice From the Consequences of Lethal Irradiation
Abstract A new transgenic mouse has been generated in which the proto-oncogene BCL-2 is ubiquitously overexpressed. H2K-BCL-2 transgenic mice overexpress BCL-2 in all cells of t...
Macrophage plasticity, polarization, and function in health and disease
Macrophages are heterogeneous and their phenotype and functions are regulated by the surrounding micro‐environment. Macrophages commonly exist in two distinct subsets: 1) Classi...
Tumor necrosis factor α induces a caspase-independent death pathway in human neutrophils
Tumor necrosis factor α (TNF-α) is a cytokine with multiple roles in the immune system, including the induction and potentiation of cellular functions in neutrophils (PMNs). TNF...
Publication Info
- Year
- 1994
- Type
- article
- Volume
- 179
- Issue
- 3
- Pages
- 1047-1052
- Citations
- 280
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
280
OpenAlex
Cite This
Eric Lagasse,
Irving L. Weissman
(1994).
bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages..
The Journal of Experimental Medicine
, 179
(3)
, 1047-1052.
https://doi.org/10.1084/jem.179.3.1047
Identifiers
- DOI
- 10.1084/jem.179.3.1047