B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

Abstract

CD28/B7 costimulation has been implicated in the induction and progression of autoimmune diseases. Experimentally induced models of autoimmunity have been shown to be prevented or reduced in intensity in mice rendered deficient for CD28 costimulation. In sharp contrast, spontaneous diabetes is exacerbated in both B7-1/B7-2-deficient and CD28-deficient NOD mice. These mice present a profound decrease of the immunoregulatory CD4+CD25+ T cells, which control diabetes in prediabetic NOD mice. These cells are absent from both CD28KO and B7-1/B7-2KO mice, and the transfer of this regulatory T cell subset from control NOD animals into CD28-deficient animals can delay/prevent diabetes. The results suggest that the CD28/ B7 costimulatory pathway is essential for the development and homeostasis of regulatory T cells that control spontaneous autoimmune diseases.

Keywords

CD28NodNOD miceAutoimmunityIL-2 receptorImmunologyBiologyHomeostasisDiabetes mellitusType 1 diabetesT cellCell biologyImmune systemEndocrinology

MeSH Terms

AbataceptAnimalsAntigensCDAntigensDifferentiationAutoimmune DiseasesB7-1 AntigenB7-2 AntigenCD28 AntigensCD4-Positive T-LymphocytesCTLA-4 AntigenDiabetes MellitusType 1FemaleHomeostasisImmunoconjugatesLymphocyte ActivationLymphokinesMaleMembrane GlycoproteinsMiceMiceInbred NODMiceKnockoutPrediabetic StateReceptorsInterleukin-2

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Publication Info

Year: 2000
Type: article
Volume: 12
Issue: 4
Pages: 431-440
Citations: 2028
Access: Closed

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APA Style

                            
                                
                                    Benoı̂t L. Salomon, 
                                
                                    Deborah J. Lenschow, 
                                
                                    Lesley Rhee
                                
                                et al.
                            
                            (2000). 
                            B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes. 
                            Immunity
                            , 12
                            (4)
                            , 431-440.
                            https://doi.org/10.1016/s1074-7613(00)80195-8
                        

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DOI: 10.1016/s1074-7613(00)80195-8
PMID: 10795741

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Data completeness: 86%

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

Abstract

Keywords

MeSH Terms

Affiliated Institutions

Related Publications

Breast cancer instructs dendritic cells to prime interleukin 13–secreting CD4+ T cells that facilitate tumor development

Disruption of the <i>Bcl6</i> Gene Results in an Impaired Germinal Center Formation

Langerhans Cell Maturation and Contact Hypersensitivity Are Impaired in Aryl Hydrocarbon Receptor-Null Mice

Differential antitumor immunity mediated by NKT cell subsets in vivo

Intraepithelial CD8<sup>+</sup>tumor-infiltrating lymphocytes and a high CD8<sup>+</sup>/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer

Publication Info

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