Abstract
Weak instrument bias is of practical importance for the design and analysis of Mendelian randomization studies. Post hoc choice of instruments, genetic models or data based on measured F-statistics can exacerbate bias. In particular, the commonly cited rule of thumb that F > 10 avoids bias in IV analysis is misleading.
Keywords
Mendelian randomizationObservational studyPoolingStatisticsStatisticCovariateEconometricsType I and type II errorsInstrumental variableStandard errorConfoundingOutcome (game theory)Causal inferenceMathematicsGeneticsComputer scienceGenetic variantsBiology
MeSH Terms
BiasConfounding FactorsEpidemiologicData InterpretationStatisticalFemaleGenetic Predisposition to DiseaseGenetic VariationGenotypeHumansMaleMendelian Randomization AnalysisRandom AllocationSensitivity and Specificity
Affiliated Institutions
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Publication Info
- Year
- 2011
- Type
- review
- Volume
- 40
- Issue
- 3
- Pages
- 755-764
- Citations
- 3803
- Access
- Closed
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Cite This
Stephen Burgess,
Simon G. Thompson
(2011).
Avoiding bias from weak instruments in Mendelian randomization studies.
International Journal of Epidemiology
, 40
(3)
, 755-764.
https://doi.org/10.1093/ije/dyr036
Identifiers
- DOI
- 10.1093/ije/dyr036
- PMID
- 21414999