Autophagy-Dependent Viral Recognition by Plasmacytoid Dendritic Cells

Abstract

Plasmacytoid dendritic cells (pDCs) detect viruses in the acidified endosomes by means of Toll-like receptors (TLRs). Yet, pDC responses to certain single-stranded RNA (ssRNA) viruses occur only after live viral infection. We present evidence here that the recognition of such viruses by TLR7 requires transport of cytosolic viral replication intermediates into the lysosome by the process of autophagy. In addition, autophagy was found to be required for the production of interferon-α by pDCs. These results support a key role for autophagy in mediating ssRNA virus detection and interferon-α secretion by pDCs and suggest that cytosolic replication intermediates of viruses serve as pathogen signatures recognized by TLR7.

Keywords

TLR7AutophagyEndosomeInterferonPlasmacytoid dendritic cellLysosomeCell biologyBiologyViral replicationVirusVirologyPicornavirusViral entryCytosolPattern recognition receptorRNAReceptorToll-like receptorDendritic cellAntigenInnate immune systemImmunologyGeneBiochemistryIntracellular

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Publication Info

Year: 2007
Type: article
Volume: 315
Issue: 5817
Pages: 1398-1401
Citations: 825
Access: Closed

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APA Style

                            
                                
                                    Heung Kyu Lee, 
                                
                                    Jennifer M. Lund, 
                                
                                    Balaji Ramanathan
                                
                                et al.
                            
                            (2007). 
                            Autophagy-Dependent Viral Recognition by Plasmacytoid Dendritic Cells. 
                            Science
                            , 315
                            (5817)
                            , 1398-1401.
                            https://doi.org/10.1126/science.1136880
                        

Identifiers

DOI: 10.1126/science.1136880