Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice

Abstract

Dilated cardiomyopathy is a severe pathology of the heart with poorly understood etiology. Disruption of the gene encoding the negative immunoregulatory receptor PD-1 in BALB/c mice, but not in BALB/c RAG-2 −/− mice, caused dilated cardiomyopathy with severely impaired contraction and sudden death by congestive heart failure. Affected hearts showed diffuse deposition of immunoglobulin G (IgG) on the surface of cardiomyocytes. All of the affected PD-1 −/− mice exhibited high-titer circulating IgG autoantibodies reactive to a 33-kilodalton protein expressed specifically on the surface of cardiomyocytes. These results indicate that PD-1 may be an important factor contributing to the prevention of autoimmune diseases.

Keywords

Dilated cardiomyopathyAutoantibodyHeart failureCardiomyopathyAutoimmunityReceptorMedicineAutoimmune diseaseAntibodyInternal medicineEndocrinologyImmunology

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Publication Info

Year: 2001
Type: article
Volume: 291
Issue: 5502
Pages: 319-322
Citations: 1817
Access: Closed

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APA Style

                            
                                
                                    Hiroyuki Nishimura, 
                                
                                    Taku Okazaki, 
                                
                                    Yoshimasa Tanaka
                                
                                et al.
                            
                            (2001). 
                            Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice. 
                            Science
                            , 291
                            (5502)
                            , 319-322.
                            https://doi.org/10.1126/science.291.5502.319
                        

Identifiers

DOI: 10.1126/science.291.5502.319