Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer

2018 New England Journal of Medicine 4,116 citations

Abstract

Atezolizumab plus nab-paclitaxel prolonged progression-free survival among patients with metastatic triple-negative breast cancer in both the intention-to-treat population and the PD-L1-positive subgroup. Adverse events were consistent with the known safety profiles of each agent. (Funded by F. Hoffmann-La Roche/Genentech; IMpassion130 ClinicalTrials.gov number, NCT02425891 .).

Keywords

AtezolizumabTriple-negative breast cancerPaclitaxelBreast cancerOncologyInternal medicineNab-paclitaxelMedicineHormone receptorCancerCancer researchImmunotherapy

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Publication Info

Year
2018
Type
article
Volume
379
Issue
22
Pages
2108-2121
Citations
4116
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Peter Schmid, Sylvia Adams, Hope S. Rugo et al. (2018). Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer. New England Journal of Medicine , 379 (22) , 2108-2121. https://doi.org/10.1056/nejmoa1809615

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DOI
10.1056/nejmoa1809615