Association of the microbiome with pre-epithelial barrier impairment in individuals with laryngopharyngeal reflux

Xiaohuan Cui; Xinxin Bi; Linxi Zhou; Xingwang Jiang; Yanping Zhang; Lina Li; Xiao-Jie Jing; Shuang Guo

doi:10.1186/s12866-025-04574-4

Abstract

Our findings demonstrate that LPR is associated with both distinct salivary microbial profiles and disruption of the pre-epithelial mucosal barrier constituents. These observations support a potential role for salivary microbiota dysbiosis in the pathogenesis of LPR, highlighting a novel interconnection between microbial community perturbations and mucosal barrier dysfunction in this disease. LEVEL OF EVIDENCE：: 4 TRIAL REGISTRATION: No. ChiCTR2400091947. Registered on November 6,2024 retrospectively.

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Year: 2025
Type: article
Citations: 0
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APA Style

                            
                                    Xiaohuan Cui, 
                                
                                    Xinxin Bi, 
                                
                                    Linxi Zhou
                                
                                et al.
                            
                            (2025). 
                            Association of the microbiome with pre-epithelial barrier impairment in individuals with laryngopharyngeal reflux. 
                            BMC Microbiology
                            
                            .
                            https://doi.org/10.1186/s12866-025-04574-4

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DOI: 10.1186/s12866-025-04574-4