Abstract
To investigate the possible relation between HLA antigens and either favourable clinical response or toxic reaction to two different gold compounds, aurothioglucose and auranofin, a new orally absorbable gold compound, we studied 50 patients with rheumatoid arthritis prospectively. Of the 25 aurothioglucose‐treated patients, response to treatment could not be evaluated in four patients because of early toxicity. Nine patients showed an excellent response, while 12 were moderate or non‐responders. Four of the 9 excellent responders were HLA‐DR3 positive, but none of the 12 moderate or non‐responders possessed this antigen ( P < 0.025). In accordance with previous reports HLA‐DR3 was found more frequently in patients developing toxicity on aurothioglucose than in those who did not (RR = 5.6). No association was found between HLA antigens and favourable clinical response in 25 auranofin‐treated patients. Two of them showed a severe adverse reaction, neither of them being DR3‐positive. HLA‐DR3 positivity is associated not only with drug toxicity, but also with excellent respondership to aurothioglucose treatment.
Keywords
AuranofinMedicineRheumatoid arthritisToxicityHuman leukocyte antigenAntigenInternal medicineDrugGastroenterologyImmunologyPharmacology
MeSH Terms
ArthritisRheumatoidAurothioglucoseDose-Response RelationshipDrugHLA AntigensHumans
Affiliated Institutions
Related Publications
Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins
Insulin-dependent diabetic (IDD) patients have a high prevalence of circulating autoantibodies against islet of Langerhans cells at the time of diagnosis1â4. Inflammatory cell...
Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA–DRB1 shared epitope for antibodies to citrullinated proteins
Abstract Objective The main genetic risk factor for rheumatoid arthritis (RA), the HLA region, has been known for 25 years. Previous research has demonstrated, within the RA pop...
Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles.
Naturally processed peptides were acid extracted from immunoaffinity-purified HLA-DR2, DR3, DR4, DR7, and DR8. Using the complementary techniques of mass spectrometry and Edman ...
Are Insulin Autoantibodies Markers for Insulin-Dependent Diabetes Mellitus?
Recent studies have shown that insulin autoantibodies occur in patients with newly diagnosed insulin-dependent diabetes mellitus (IDDM) before exogenous insulin treatment. Our s...
Although DR3-DQB1*0201 may be associated with multiple component diseases of the autoimmune polyglandular syndromes, the human leukocyte antigen DR4-DQB1*0302 haplotype is implicated only in beta-cell autoimmunity.
Human leukocyte antigen (HLA)-DRB1 and -DQB1 alleles were analyzed using a PCR-based sequence-specific priming technique in 16 patients with autoimmune polyglandular syndrome ty...
Publication Info
- Year
- 1983
- Type
- article
- Volume
- 22
- Issue
- 3
- Pages
- 194-199
- Citations
- 43
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
43
OpenAlex
0
Influential
30
CrossRef
Cite This
Piet L. C. M. van Riel,
P. Reekers,
Levinus B. A. van de Putte
et al.
(1983).
Association of HLA antigens, toxic reactions and therapeutic response to auranofin and aurothioglucose in patients with rheumatoid arthritis.
Tissue Antigens
, 22
(3)
, 194-199.
https://doi.org/10.1111/j.1399-0039.1983.tb01191.x
Identifiers
- DOI
- 10.1111/j.1399-0039.1983.tb01191.x
- PMID
- 6415865