Association of Aβ40-positive Senile Plaques with Microglial Cells in the Brains of Patients with Alzheimer's Disease and in Non-demented Aged Individuals

Keywords

MicrogliaSenile plaquesBETA (programming language)FerritinAlzheimer's diseaseAmyloid (mycology)Amyloid betaPathologyDiseaseBiologyMedicineImmunologyInflammation

Affiliated Institutions

Related Publications

Neuropathology of synuclein aggregates

John E. Duda , Virginia M.‐Y. Lee , John Q. Trojanowski

Beginning with the isolation of the fragment of alpha-synuclein (alpha-syn) known as the non-Abeta component of amyloid plaques (NAC peptide) from Alzheimer's disease (AD) brain...

2000 Journal of Neuroscience Research 263 citations

Human amyloid β‐induced neuroinflammation is an early event in neurodegeneration

Jeffrey M. Craft , D. Martin Watterson , Linda J. Van Eldik

Abstract Using a human amyloid β (Aβ) intracerebroventricular infusion mouse model of Alzheimer's disease‐related injury, we previously demonstrated that systemic administration...

2005 Glia 109 citations

Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils

Jürgen Götz , F. Chen , Jo Van Dorpe +1 more

β-Amyloid plaques and neurofibrillary tangles (NFTs) are the defining neuropathological hallmarks of Alzheimer's disease, but their pathophysiological relation is unclear. Injec...

2001 Science 1499 citations

Induction of Tau Pathology by Intracerebral Infusion of Amyloid-β-Containing Brain Extract and by Amyloid-β Deposition in APP × Tau Transgenic Mice

Tristan Bolmont , Florence Clavaguera , Melanie Meyer‐Luehmann +7 more

Alzheimer's disease presents morphologically with senile plaques, primarily made of extracellular amyloid-beta (A beta) deposits, and neurofibrillary lesions, which consist of i...

2007 American Journal Of Pathology 261 citations

Tau is essential to β-amyloid-induced neurotoxicity

Mark Rapoport , Hana N. Dawson , Lester I. Binder +2 more

Senile plaques and neurofibrillary tangles, the two hallmark lesions of Alzheimer's disease, are the results of the pathological deposition of proteins normally present througho...

2002 Proceedings of the National Academy o... 793 citations

Publication Info

Year: 1996
Type: article
Volume: 5
Issue: 1
Pages: 13-17
Citations: 66
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Association of Aβ40-positive Senile Plaques with Microglial Cells in the Brains of Patients with Alzheimer's Disease and in Non-demented Aged Individuals

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

OpenAlex

Cite This

APA Style

                            
                                
                                    Hiroaki Fukumoto, 
                                
                                    Asano Asami-Odaka, 
                                
                                    Nobuhiro Suzuki
                                
                                et al.
                            
                            (1996). 
                            Association of Aβ40-positive Senile Plaques with Microglial Cells in the Brains of Patients with Alzheimer's Disease and in Non-demented Aged Individuals. 
                            Neurodegeneration
                            , 5
                            (1)
                            , 13-17.
                            https://doi.org/10.1006/neur.1996.0002
                        

Identifiers

DOI: 10.1006/neur.1996.0002