Abstract
Apoptosis, the cell’s natural mechanism for death, is a promising target for anticancer therapy. Both the intrinsic and extrinsic pathways use caspases to carry out apoptosis through the cleavage of hundreds of proteins. In cancer, the apoptotic pathway is typically inhibited through a wide variety of means including overexpression of antiapoptotic proteins and under-expression of proapoptotic proteins. Many of these changes cause intrinsic resistance to the most common anticancer therapy, chemotherapy. Promising new anticancer therapies are plant-derived compounds that exhibit anticancer activity through activating the apoptotic pathway.
Keywords
ApoptosisCaspaseIntrinsic apoptosisProgrammed cell deathCancer researchCancer therapyBiologyMechanism (biology)Cell biologyCancerChemistryBioinformaticsBiochemistryGenetics
MeSH Terms
AnimalsAntineoplastic AgentsPhytogenicApoptosisCarcinogenesisCaspasesCell LineTumorCurcuminFas Ligand ProteinGene Expression RegulationNeoplasticHumansMiceMolecular Targeted TherapyNeoplasmsProto-Oncogene Proteins c-bcl-2Signal Transductionbcl-2-Associated X Proteinfas Receptor
Affiliated Institutions
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Publication Info
- Year
- 2018
- Type
- review
- Volume
- 19
- Issue
- 2
- Pages
- 448-448
- Citations
- 1480
- Access
- Closed
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Cite This
Claire M. Pfeffer,
Amareshwar T.K. Singh
(2018).
Apoptosis: A Target for Anticancer Therapy.
International Journal of Molecular Sciences
, 19
(2)
, 448-448.
https://doi.org/10.3390/ijms19020448
Identifiers
- DOI
- 10.3390/ijms19020448
- PMID
- 29393886
- PMCID
- PMC5855670