Abstract
Porcine insulin, which is distinguished from human insulin only in the amino acid at the C terminal of the B chain, is antigenic in man. Even if the last amino acid or the last eight amino acids are removed from the C terminus of the B chain of insulin, the altered insulin still reacts with human antibodies to porcine insulin; thus, the antigenic determinant of porcine insulin is located in a part of the molecule where the amino acid sequence is the same as it is in the corresponding part of the human insulin molecule.
Keywords
InsulinHuman insulinAmino acidPeptide sequenceAntigenAntibodyBiochemistryPeptideBiologyAmino acid residueChemistryEndocrinologyGeneticsGene
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Publication Info
- Year
- 1963
- Type
- article
- Volume
- 139
- Issue
- 3557
- Pages
- 844-845
- Citations
- 72
- Access
- Closed
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Cite This
Solomon A. Berson,
Rosalyn S. Yalow
(1963).
Antigens in Insulin Determinants of Specificity of Porcine Insulin in Man.
Science
, 139
(3557)
, 844-845.
https://doi.org/10.1126/science.139.3557.844
Identifiers
- DOI
- 10.1126/science.139.3557.844