Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity

Abstract

Limited knowledge is available on the relationship between antigen-specific immune responses and COVID-19 disease severity. The adaptive immune system responds to pathogens in an antigen-specific manner to develop protective immunity. We completed a combined examination of all three branches of adaptive immunity at the level of SARS-CoV-2-specific CD4+ and CD8+ T cell and neutralizing antibody responses in acute and convalescent subjects, and compared the response in unexposed controls

Keywords

BiologyImmunityCoronavirus disease 2019 (COVID-19)ImmunologyAcquired immune systemSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Immune systemDisease2019-20 coronavirus outbreakAntigenVirologyBetacoronavirusInfectious disease (medical specialty)Internal medicineMedicineOutbreak

MeSH Terms

Acute DiseaseAdaptive ImmunityAdultAgedAged80 and overAntibodiesNeutralizingAntibodiesViralAntigensViralBetacoronavirusCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCOVID-19Coronavirus InfectionsCytokinesFemaleHumansMaleMiddle AgedPandemicsPneumoniaViralSARS-CoV-2Severity of Illness IndexYoung Adult

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Publication Info

Year: 2020
Type: article
Volume: 183
Issue: 4
Pages: 996-1012.e19
Citations: 1920
Access: Closed

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APA Style

                            
                                
                                    Carolyn Rydyznski Moderbacher, 
                                
                                    Sydney I. Ramirez, 
                                
                                    Jennifer M. Dan
                                
                                et al.
                            
                            (2020). 
                            Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity. 
                            Cell
                            , 183
                            (4)
                            , 996-1012.e19.
                            https://doi.org/10.1016/j.cell.2020.09.038
                        

Identifiers

DOI: 10.1016/j.cell.2020.09.038
PMID: 33010815
PMCID: PMC7494270

Data Quality

Data completeness: 90%