Abstract
Biofilm is a complex structure of microbiome having different bacterial colonies or single type of cells in a group; adhere to the surface. These cells are embedded in extracellular polymeric substances, a matrix which is generally composed of eDNA, proteins and polysaccharides, showed high resistance to antibiotics. It is one of the major causes of infection persistence especially in nosocomial settings through indwelling devices. Quorum sensing plays an important role in regulating the biofilm formation. There are many approaches being used to control infections by suppressing its formation but CRISPR-CAS (gene editing technique) and photo dynamic therapy (PDT) are proposed to be used as therapeutic approaches to subside bacterial biofim infections, especially caused by deadly drug resistant bad bugs.
Keywords
BiofilmQuorum sensingMicrobiomeAntibioticsMicrobiologyMedical microbiologyAntibiotic resistanceExtracellular polysaccharideDrug resistanceCRISPRExtracellular polymeric substanceBiologyBacteriaMedicineGeneBioinformaticsGenetics
MeSH Terms
Anti-Bacterial AgentsBacterial InfectionsBiofilmsDrug ResistanceBacterialHumansMicrobiotaPhotochemotherapyQuorum Sensing
Affiliated Institutions
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Publication Info
- Year
- 2019
- Type
- review
- Volume
- 8
- Issue
- 1
- Pages
- 76-76
- Citations
- 1429
- Access
- Closed
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Cite This
Divakar Sharma,
Lama Misba,
Asad U. Khan
(2019).
Antibiotics versus biofilm: an emerging battleground in microbial communities.
Antimicrobial Resistance and Infection Control
, 8
(1)
, 76-76.
https://doi.org/10.1186/s13756-019-0533-3
Identifiers
- DOI
- 10.1186/s13756-019-0533-3
- PMID
- 31131107
- PMCID
- PMC6524306