Abstract
A novel infectious disease, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was detected in Wuhan, China, in December 2019. The disease (COVID-19) spread rapidly, reaching epidemic proportions in China, and has been found in 27 other countries. As of February 27, 2020, over 82,000 cases of COVID-19 were reported, with > 2800 deaths. No specific therapeutics are available, and current management includes travel restrictions, patient isolation, and supportive medical care. There are a number of pharmaceuticals already being tested [1, 2], but a better understanding of the underlying pathobiology is required. In this context, this article will briefly review the rationale for angiotensin-converting enzyme 2 (ACE2) receptor as a specific target.
Keywords
MedicineAngiotensin-converting enzyme 2Peptidyl-Dipeptidase ASevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Pain medicineCoronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakAnesthesiologyAngiotensin-converting enzymeRenin–angiotensin systemReceptorEnzymePharmacologyInternal medicineVirologyAnesthesiaBlood pressureBiochemistryDiseaseBiologyInfectious disease (medical specialty)
MeSH Terms
Alveolar Epithelial CellsAngiotensin-Converting Enzyme 2BetacoronavirusHumansPeptidyl-Dipeptidase ARNAViralReceptorsVirusRespiratory Distress SyndromeSARS-CoV-2Severe Acute Respiratory SyndromeSpike GlycoproteinCoronavirusViral Envelope Proteins
Affiliated Institutions
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Publication Info
- Year
- 2020
- Type
- article
- Volume
- 46
- Issue
- 4
- Pages
- 586-590
- Citations
- 2771
- Access
- Closed
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Cite This
Haibo Zhang,
Josef Penninger,
Yimin Li
et al.
(2020).
Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target.
Intensive Care Medicine
, 46
(4)
, 586-590.
https://doi.org/10.1007/s00134-020-05985-9
Identifiers
- DOI
- 10.1007/s00134-020-05985-9
- PMID
- 32125455
- PMCID
- PMC7079879