Abstract

Angiogenesis is thought to depend on a precise balance of positive and negative regulation. Angiopoietin-1 (Ang1) is an angiogenic factor that signals through the endothelial cell–specific Tie2 receptor tyrosine kinase. Like vascular endothelial growth factor, Ang1 is essential for normal vascular development in the mouse. An Ang1 relative, termed angiopoietin-2 (Ang2), was identified by homology screening and shown to be a naturally occurring antagonist for Ang1 and Tie2. Transgenic overexpression of Ang2 disrupts blood vessel formation in the mouse embryo. In adult mice and humans, Ang2 is expressed only at sites of vascular remodeling. Natural antagonists for vertebrate receptor tyrosine kinases are atypical; thus, the discovery of a negative regulator acting on Tie2 emphasizes the need for exquisite regulation of this angiogenic receptor system.

Keywords

Angiopoietin receptorAngiogenesisAngiopoietinReceptor tyrosine kinaseBiologyGenetically modified mouseCell biologyVascular endothelial growth factorReceptorRegulatorTyrosine kinaseEndocrinologyCancer researchTransgeneKinaseSignal transductionBiochemistryVEGF receptorsGene

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Publication Info

Year
1997
Type
article
Volume
277
Issue
5322
Pages
55-60
Citations
3512
Access
Closed

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Peter C. Maisonpierre, Chitra Suri, Pamela F. Jones et al. (1997). Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis. Science , 277 (5322) , 55-60. https://doi.org/10.1126/science.277.5322.55

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DOI
10.1126/science.277.5322.55