Angiogenesis Induced by "Normal" Human Breast Tissue: A Probable Marker for Precancer

Hanne M. Jensen; Ibsen Chen; Martin R. DeVault; Alvin E. Lewis

doi:10.1126/science.6181563

Abstract

Normal human breast lobules, freshly isolated by precision microdissection of tissue stained with methylene blue chloride, were assayed for their ability to induce neovascularization (angiogenesis) in rabbit irises. Histologically, normal lobules from cancerous breasts induced angiogenesis twice as often as lobules from noncancerous breasts, suggesting that preneoplastic transformation is diffuse.

Keywords

MicrodissectionAngiogenesisHuman breastPathologyNeovascularizationLaser capture microdissectionBreast cancerBiologyMethylene blueCancerMedicineCancer researchBiochemistryGene

Affiliated Institutions

University of California, Davis US

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Publication Info

Year: 1982
Type: article
Volume: 218
Issue: 4569
Pages: 293-295
Citations: 126
Access: Closed

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APA Style

                            
                                
                                    Hanne M. Jensen, 
                                
                                    Ibsen Chen, 
                                
                                    Martin R. DeVault
                                
                                et al.
                            
                            (1982). 
                            Angiogenesis Induced by "Normal" Human Breast Tissue: A Probable Marker for Precancer. 
                            Science
                            , 218
                            (4569)
                            , 293-295.
                            https://doi.org/10.1126/science.6181563
                        

Identifiers

DOI: 10.1126/science.6181563