Abstract
Mouse mammary papillomas elicit new formation of vessels when transplanted onto the rabbit iris. This angiogenic capacity is a property of carcinomas but not of the resting mammary gland. In mouse papillary hyperplasias, however, this property appears much earlier than any morphological or clinical sign of carcinoma. A test for angiogenic capacity may reveal a step in the progression toward clinical malignancy and thus could be used to screen for neoplastic potential of hyperplastic epithelium in biopsy tissues.
Keywords
PathologyHyperplasiaNeoplastic transformationMalignancyEpitheliumAngiogenesisMammary glandPapillomaMammary carcinomaBiopsyMalignant transformationBiologyCarcinomaCancerBreast cancerMedicineCancer researchCarcinogenesisInternal medicine
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Publication Info
- Year
- 1977
- Type
- article
- Volume
- 195
- Issue
- 4281
- Pages
- 880-882
- Citations
- 157
- Access
- Closed
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Cite This
Steven Brem,
Pietro M. Gullino,
Daniel Medina
(1977).
Angiogenesis: A Marker for Neoplastic Transformation of Mammary Papillary Hyperplasia.
Science
, 195
(4281)
, 880-882.
https://doi.org/10.1126/science.402692
Identifiers
- DOI
- 10.1126/science.402692