Abstract
The comparison of multiple genomes demonstrates that the M. tuberculosis genome is currently undergoing an active process of gene decay, analogous to the adaptation process of obligate bacterial symbionts. This observation opens new perspectives into the evolution and the understanding of the pathogenesis of this bacterium.
Keywords
GenomeBiologyGeneticsComparative genomicsGenomicsGenetic variationVirulenceGeneGenome evolutionMycobacterium tuberculosisSingle-nucleotide polymorphismBacterial genome sizeStructural variationComputational biologyGenotypeTuberculosis
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Publication Info
- Year
- 2008
- Type
- article
- Volume
- 1
- Issue
- 1
- Pages
- 110-110
- Citations
- 37
- Access
- Closed
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Cite This
Andrés Cubillos-Ruiz,
Juan Francisco Morales,
María Mercedes Zambrano
(2008).
Analysis of the genetic variation in Mycobacterium tuberculosis strains by multiple genome alignments.
BMC Research Notes
, 1
(1)
, 110-110.
https://doi.org/10.1186/1756-0500-1-110
Identifiers
- DOI
- 10.1186/1756-0500-1-110