Analysis of Single-Cell RNA-Seq Identifies Cell-Cell Communication Associated with Tumor Characteristics

Manu P. Kumar; Jinyan Du; Georgia Lagoudas; Jiao Yang; Andrew Sawyer; Daryl C. Drummond; Douglas A. Lauffenburger; Andreas Raue

doi:10.1016/j.celrep.2018.10.047

Keywords

BiologyTumor microenvironmentCellReceptorImmune systemComputational biologyPhenotypeLigand (biochemistry)RNACell typeMelanomaImmune checkpointCancer researchImmunotherapyImmunologyGeneticsGene

Affiliated Institutions

Related Publications

The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications

Yuanyuan Zhang , Zemin Zhang

Abstract Immunotherapy has revolutionized cancer treatment and rejuvenated the field of tumor immunology. Several types of immunotherapy, including adoptive cell transfer (ACT) ...

2020 Cellular and Molecular Immunology 2559 citations

Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment

Elham Azizi , Ambrose Carr , George Plitas +16 more

Knowledge of immune cell phenotypes in the tumor microenvironment is essential for understanding mechanisms of cancer progression and immunotherapy response. We profiled 45,000 ...

2018 Cell 1993 citations

PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors

Michael A. Curran , Welby Montalvo , Hideo Yagita∥ +1 more

Vaccination with irradiated B16 melanoma cells expressing either GM-CSF (Gvax) or Flt3-ligand (Fvax) combined with antibody blockade of the negative T-cell costimulatory recepto...

2010 Proceedings of the National Academy o... 1833 citations

Restoring Immune Function of Tumor-Specific CD4+ T Cells during Recurrence of Melanoma

Stephen R. Goding , Kyle Wilson , Ying Xie +7 more

Abstract Recurrent solid malignancies are often refractory to standard therapies. Although adoptive T cell transfer may benefit select individuals, the majority of patients succ...

2013 The Journal of Immunology 204 citations

CD8<sup>+</sup> cytotoxic T lymphocytes in cancer immunotherapy: A review

Bagher Farhood , Masoud Najafi , Keywan Mortezaee

Abstract CD8 + cytotoxic T lymphocytes (CTLs) are preferred immune cells for targeting cancer. During cancer progression, CTLs encounter dysfunction and exhaustion due to immune...

2018 Journal of Cellular Physiology 1662 citations

Publication Info

Year: 2018
Type: article
Volume: 25
Issue: 6
Pages: 1458-1468.e4
Citations: 445
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Analysis of Single-Cell RNA-Seq Identifies Cell-Cell Communication Associated with Tumor Characteristics

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

445

OpenAlex

Cite This

APA Style

                            
                                
                                    Manu P. Kumar, 
                                
                                    Jinyan Du, 
                                
                                    Georgia Lagoudas
                                
                                et al.
                            
                            (2018). 
                            Analysis of Single-Cell RNA-Seq Identifies Cell-Cell Communication Associated with Tumor Characteristics. 
                            Cell Reports
                            , 25
                            (6)
                            , 1458-1468.e4.
                            https://doi.org/10.1016/j.celrep.2018.10.047
                        

Identifiers

DOI: 10.1016/j.celrep.2018.10.047