An atlas of the protein-coding genes in the human, pig, and mouse brain

Abstract

Mapping the mammalian brain The diverse physiology of the brain is reflected in its complex organization at regional, cellular, and subcellular levels. Sjöstedt et al. combined data—both newly acquired and from other large-scale brain mapping projects—from transcriptomics, single-cell genomics, in situ hybridization, and antibody-based protein profiling to map the molecular profiles in human, pig, and mouse brain. The analysis is consistent with a conserved basic brain architecture during mammalian evolution, but it does show differences in regional gene expression profiles. Science , this issue p. eaay5947

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Affiliated Institutions

• Science for Life Laboratory SE
• BGI Group (China) CN
• Uppsala University SE
• China National GeneBank CN
• University of Copenhagen DK
• Karolinska Institutet SE
• Aarhus University DK
• KTH Royal Institute of Technology SE

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