Amplification and over-expression of the neu oncogene in human breast carcinomas.

Abstract

Amplification of the neu (or c-erbB-2 or HER) oncogene is found to be present in 15-30% of human breast carcinomas and has been reported to correlate with poor prognosis. We briefly review the literature on this subject with emphasis on our own results on immunohistochemical detection of neu overproduction in paraffin embedded tissue sections of human breast carcinomas.

Keywords

MedicineImmunohistochemistryOncogeneHuman breastMammary glandCancer researchCarcinomaBreast cancerPathologyOncologyInternal medicineCancerCell cycle

Affiliated Institutions

The Netherlands Cancer Institute NL

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Publication Info

Year: 1988
Type: article
Volume: 14
Issue: 2
Pages: 111-4
Citations: 31
Access: Closed

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APA Style

                            
                                    Marc J. van de Vijver, 
                                
                                    W. J. Mooi, 
                                
                                    J.L. Peterse
                                
                                et al.
                            
                            (1988). 
                            Amplification and over-expression of the neu oncogene in human breast carcinomas.. 
                            PubMed
                            , 14
                            (2)
                            , 111-4.