Abstract
In its earliest clinical phase, Alzheimer's disease characteristically produces a remarkably pure impairment of memory. Mounting evidence suggests that this syndrome begins with subtle alterations of hippocampal synaptic efficacy prior to frank neuronal degeneration, and that the synaptic dysfunction is caused by diffusible oligomeric assemblies of the amyloid β protein.
Keywords
NeuroscienceHippocampal formationDiseaseDegeneration (medical)Alzheimer's diseaseHippocampusAmyloid (mycology)PsychologyBiologyMedicinePathology
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Publication Info
- Year
- 2002
- Type
- review
- Volume
- 298
- Issue
- 5594
- Pages
- 789-791
- Citations
- 4309
- Access
- Closed
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Cite This
Dennis J. Selkoe
(2002).
Alzheimer's Disease Is a Synaptic Failure.
Science
, 298
(5594)
, 789-791.
https://doi.org/10.1126/science.1074069
Identifiers
- DOI
- 10.1126/science.1074069