Keywords
Stem cellLeukemiaHaematopoiesisBiologyMyeloid leukemiaTransplantationCancer stem cellCancer researchImmunologyMyeloidCell biologyMedicineInternal medicine
Affiliated Institutions
Related Publications
Normal and leukemic hematopoiesis: Are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?
Leukemia can be viewed as a newly formed, abnormal hematopoietic tissue initiated by a few leukemic stem cells (LSCs) that undergo an aberrant and poorly regulated process of or...
Evidence for malignant transformation in acute myeloid leukemia at the level of early hematopoietic stem cells by cytogenetic analysis of CD34+ subpopulations
Abstract Acute myeloid leukemia (AML) is a heterogenous disease according to morphology, immunophenotype, and genetics. The retained capacity of differentiation is the basis for...
Normal and leukemic human stem cells assayed in SCID mice
Understanding the processes that regulate the developmental program of normal stem cells and those that initiate proliferative diseases such as leukemia remains one of the major...
Identification of a cancer stem cell in human brain tumors.
Most current research on human brain tumors is focused on the molecular and cellular analysis of the bulk tumor mass. However, there is overwhelming evidence in some malignancie...
Characterization of a hierarchy in human acute myeloid leukemia progenitor cells
Despite the usual uniform and primitive appearance of cells derived from the leukemic clone in most patients with acute myeloid leukemia (AML), there is considerable heterogenei...
Publication Info
- Year
- 2004
- Type
- article
- Volume
- 5
- Issue
- 7
- Pages
- 738-743
- Citations
- 968
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
968
OpenAlex
Cite This
Kristin J. Hope,
Liqing Jin,
John E. Dick
(2004).
Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity.
Nature Immunology
, 5
(7)
, 738-743.
https://doi.org/10.1038/ni1080
Identifiers
- DOI
- 10.1038/ni1080