Keywords
BiologyEndoplasmic reticulumUnfolded protein responseCell biologyTransmembrane proteinSignal transductionER retentionCytoplasmMutantBiochemistryGeneReceptor
Affiliated Institutions
Related Publications
On the mechanism of sensing unfolded protein in the endoplasmic reticulum
Unfolded proteins in the endoplasmic reticulum (ER) activate the ER transmembrane sensor Ire1 to trigger the unfolded protein response (UPR), a homeostatic signaling pathway tha...
Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1
Malfolded proteins in the endoplasmic reticulum (ER) induce cellular stress and activate c-Jun amino-terminal kinases (JNKs or SAPKs). Mammalian homologs of yeast IRE1, which ac...
The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response
The unfolded protein response (UPR) is an evolutionarily conserved mechanism by which all eukaryotic cells adapt to the accumulation of unfolded proteins in the endoplasmic reti...
Mammalian Transcription Factor ATF6 Is Synthesized as a Transmembrane Protein and Activated by Proteolysis in Response to Endoplasmic Reticulum Stress
The unfolded protein response (UPR) controls the levels of molecular chaperones and enzymes involved in protein folding in the endoplasmic reticulum (ER). We recently isolated A...
Mechanisms, regulation and functions of the unfolded protein response
Cellular stress induced by the abnormal accumulation of unfolded or misfolded proteins at the endoplasmic reticulum (ER) is emerging as a possible driver of human diseases, incl...
Publication Info
- Year
- 1993
- Type
- article
- Volume
- 74
- Issue
- 4
- Pages
- 743-756
- Citations
- 814
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
814
OpenAlex
Cite This
Kazutoshi Morl,
Wenzhen Ma,
Mary‐Jane Gething
et al.
(1993).
A transmembrane protein with a cdc2+CDC28-related kinase activity is required for signaling from the ER to the nucleus.
Cell
, 74
(4)
, 743-756.
https://doi.org/10.1016/0092-8674(93)90521-q
Identifiers
- DOI
- 10.1016/0092-8674(93)90521-q