Abstract
Among patients at high risk for cardiovascular events but without diabetes, targeting a systolic blood pressure of less than 120 mm Hg, as compared with less than 140 mm Hg, resulted in lower rates of fatal and nonfatal major cardiovascular events and death from any cause, although significantly higher rates of some adverse events were observed in the intensive-treatment group. (Funded by the National Institutes of Health; ClinicalTrials.gov number, NCT01206062.).
Keywords
Blood pressureMedicineRandomized controlled trialDiabetes mellitusCardiologyIntensive care medicineInternal medicineEmergency medicineEndocrinology
Affiliated Institutions
Related Publications
Effects of Intensive Blood-Pressure Control in Type 2 Diabetes Mellitus
In patients with type 2 diabetes at high risk for cardiovascular events, targeting a systolic blood pressure of less than 120 mm Hg, as compared with less than 140 mm Hg, did no...
Target Blood Pressure for Treatment of Isolated Systolic Hypertension in the Elderly
In this prospective, randomized, open-label, blinded end point study, we aimed to establish whether strict blood pressure control (<140 mm Hg) is superior to moderate blood p...
Improved Hypertension Management and Control
A survey in 1994 showed that among the 20% of the adult English population who were identified as hypertensive, ≈30% had their blood pressures controlled to <160 mm Hg systol...
Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure
The National High Blood Pressure Education Program presents the complete Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of Hi...
Association of systolic blood pressure with macrovascular and microvascular complications of type 2 diabetes (UKPDS 36): prospective observational study
In patients with type 2 diabetes the risk of diabetic complications was strongly associated with raised blood pressure. Any reduction in blood pressure is likely to reduce the r...
Publication Info
- Year
- 2015
- Type
- article
- Volume
- 373
- Issue
- 22
- Pages
- 2103-2116
- Citations
- 5933
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
5933
OpenAlex
Cite This
The SPRINT Research Group,
The SPRINT Research Group
(2015).
A Randomized Trial of Intensive versus Standard Blood-Pressure Control.
New England Journal of Medicine
, 373
(22)
, 2103-2116.
https://doi.org/10.1056/nejmoa1511939
Identifiers
- DOI
- 10.1056/nejmoa1511939