Abstract

Two nontoxic, antimicrobial nanoemulsions, BCTP and BCTP 401, have been developed. These emulsions are composed of detergents and oils in 80% water. BCTP diluted up to 1:1000 inactivated>90% of Bacillus anthracis spores in 4 h and was also sporicidal against three other Bacillus species. This sporicidal activity is due to disruption of the spore coat after initiation of germination without complete outgrowth. BCTP 401 diluted 1:1000 had greater activity than BCTP against Bacillus spores and had an onset of action of <30 min. Mixing BCTP or BCTP 401 with Bacillus cereus prior to subcutaneous injection in mice reduced the resulting skin lesion by 99%. Wound irrigation with BCTP 1 h after spore inoculation yielded a 98% reduction in skin lesion size, and mortality was reduced 3-fold. These nanoemulsion formulas are stable, easily dispersed, nonirritant, and nontoxic compared with other available sporicidal agents.

Keywords

SporeBacillus cereusMicrobiologyBacillus anthracisAntimicrobialPulmonary surfactantChemistryGerminationBroad spectrumBacillus (shape)Food scienceBiologyBacteriaBiochemistryBotany

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Year
1999
Type
article
Volume
180
Issue
6
Pages
1939-1949
Citations
201
Access
Closed

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Cite This

Tarek Hamouda, Michael M. Hayes, Zhengyi Cao et al. (1999). A Novel Surfactant Nanoemulsion with Broad‐Spectrum Sporicidal Activity against<i>Bacillus</i>Species. The Journal of Infectious Diseases , 180 (6) , 1939-1949. https://doi.org/10.1086/315124

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DOI
10.1086/315124