A new method for the synthesis of magnetoliposomes

Claudio Sangregorio; Joan K. Wiemann; Charles J. O’Connor; Zeev Rosenzweig

doi:10.1063/1.370256

Abstract

A new method for the synthesis of magnetoliposomes, i.e., nanosized magnetic particles coated by a phospholipid membrane, is presented. Magnetoliposomes are prepared by directly using the phospholipid vesicles as nanoreactors for the precipitation of the magnetic particles. The magnetoliposomes have been characterized using transmission electron microscopy imaging and x-ray powder diffraction. The magnetic properties of the magnetoliposomes have been investigated with a superconducting quantum interference device magnetometer. Our results indicate that the magnetoliposomes contain approximately spherical maghemite nanoparticles averaging 25 nm in diameter. The occurrence of a phospholipid bilayer surrounding the magnetic particles is confirmed both by transmission electron micrographs of samples negatively stained with uranyl acetate and by digital fluorescence imaging microscopy measurements of magnetoliposomes labeled with fluorescein. The temperature dependence of the zero field cooled and field cooled susceptibilities of the magnetoliposomes is consistent with their expected superparamagnetic nature.

Keywords

SuperparamagnetismMaterials scienceTransmission electron microscopyMagnetic nanoparticlesNanotechnologyNanoparticleUranyl acetateAnalytical Chemistry (journal)ChemistryElectron microscopeMagnetic fieldMagnetizationChromatographyOptics

Affiliated Institutions

University of New Orleans US

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Publication Info

Year: 1999
Type: article
Volume: 85
Issue: 8
Pages: 5699-5701
Citations: 60
Access: Closed

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APA Style

                            
                                
                                    Claudio Sangregorio, 
                                
                                    Joan K. Wiemann, 
                                
                                    Charles J. O’Connor
                                
                                et al.
                            
                            (1999). 
                            A new method for the synthesis of magnetoliposomes. 
                            Journal of Applied Physics
                            , 85
                            (8)
                            , 5699-5701.
                            https://doi.org/10.1063/1.370256
                        

Identifiers

DOI: 10.1063/1.370256

Data Quality

Data completeness: 81%