A new measure for functional similarity of gene products based on Gene Ontology

Abstract

The approach enables the comparison of the underlying molecular biology of different taxonomic groups and provides a new comparative genomics tool identifying functionally related gene products independent of homology. The proposed map of the functional space provides a new global view on the functional relationships between gene products or protein families.

Keywords

Semantic similarityComputational biologyFunctional genomicsSimilarity (geometry)BiologyGene ontologyGeneFunction (biology)Gene AnnotationDNA microarrayGenomeGenomicsComputer scienceGeneticsArtificial intelligenceGene expression

Affiliated Institutions

Max Planck Institute for Informatics DE

Related Publications

The Gene Ontology resource: enriching a GOld mine

Seth Carbon , Eric Douglass , Benjamin M. Good +97 more

Abstract The Gene Ontology Consortium (GOC) provides the most comprehensive resource currently available for computable knowledge regarding the functions of genes and gene produ...

2020 Nucleic Acids Research 3586 citations

The Gene Ontology Resource: 20 years and still GOing strong

Seth Carbon

The Gene Ontology resource (GO; http://geneontology.org) provides structured, computable knowledge regarding the functions of genes and gene products. Founded in 1998, GO has be...

2018 Nucleic Acids Research 4845 citations

KEGG for taxonomy-based analysis of pathways and genomes

Minoru Kanehisa , Miho Furumichi , Yoko Sato +2 more

Abstract KEGG (https://www.kegg.jp) is a manually curated database resource integrating various biological objects categorized into systems, genomic, chemical and health informa...

2022 Nucleic Acids Research 5892 citations

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

Damian Szklarczyk , Annika L Gable , David Lyon +9 more

Proteins and their functional interactions form the backbone of the cellular machinery. Their connectivity network needs to be considered for the full understanding of biologica...

2018 Nucleic Acids Research 18024 citations

The SWISS-PROT protein knowledgebase and its supplement TrEMBL in 2003

Brigitte Boeckmann , Amos Bairoch , Rolf Apweiler +9 more

The SWISS-PROT protein knowledgebase (http://www.expasy.org/sprot/ and http://www.ebi.ac.uk/swissprot/) connects amino acid sequences with the current knowledge in the Life Scie...

2003 Nucleic Acids Research 3907 citations

Publication Info

Year: 2006
Type: article
Volume: 7
Issue: 1
Pages: 302-302
Citations: 706
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

A new measure for functional similarity of gene products based on Gene Ontology

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

706

OpenAlex

Cite This

APA Style

                            
                                
                                    Andreas Schlicker, 
                                
                                    Francisco S. Domingues, 
                                
                                    Jörg Rahnenführer
                                
                                et al.
                            
                            (2006). 
                            A new measure for functional similarity of gene products based on Gene Ontology. 
                            BMC Bioinformatics
                            , 7
                            (1)
                            , 302-302.
                            https://doi.org/10.1186/1471-2105-7-302
                        

Identifiers

DOI: 10.1186/1471-2105-7-302