A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

Keywords

Ataxia-telangiectasiaGadd45BiologyDNA damageCell cycle checkpointCell cycleNijmegen breakage syndromeDNA repairG2-M DNA damage checkpointMutantGeneWild typeCell biologyCancer researchMutationMolecular biologyDNAGenetics

Affiliated Institutions

Related Publications

<b>A gain of function p53 mutant promotes both genomic instability and cell survival in a novel p53‐null mammary epithelial cell mode</b> .

Kristen L Murphy , Andrew P. Dennis , Jeffrey M. Rosen

ABSTRACT Approximately 40% of human breast cancers contain alterations in the tumor suppressor p53. The p53 172R‐H gain‐of‐function mutant (equivalent to the common 175R‐H human...

2000 The FASEB Journal 93 citations

Mismatch repair deficient human cells: spontaneous and MNNG-induced mutational spectra in the HPRT gene

Aoy Tomita‐Mitchell , Alexandra G. Kat , Luisa A. Marcelino +3 more

2000 Mutation research. Fundamental and mo... 41 citations

Author response: DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis

Ben Taylor , Serena Nik‐Zainal , Yee Ling Wu +6 more

Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Me...

2013 4 citations

Cancer immunotherapy using checkpoint blockade

Antoni Ribas , Jedd D. Wolchok

The release of negative regulators of immune activation (immune checkpoints) that limit antitumor responses has resulted in unprecedented rates of long-lasting tumor responses i...

2018 Science 6236 citations

Significance analysis of microarrays applied to the ionizing radiation response

Virginia Goss Tusher , Robert Tibshirani , Gilbert Chu

Microarrays can measure the expression of thousands of genes to identify changes in expression between different biological states. Methods are needed to determine the significa...

2001 Proceedings of the National Academy o... 10601 citations

Publication Info

Year: 1992
Type: article
Volume: 71
Issue: 4
Pages: 587-597
Citations: 3077
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

3077

OpenAlex

Cite This

APA Style

                            
                                
                                    Michael B. Kastan, 
                                
                                    Qimin Zhan, 
                                
                                    Wafik S. El‐Deiry
                                
                                et al.
                            
                            (1992). 
                            A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. 
                            Cell
                            , 71
                            (4)
                            , 587-597.
                            https://doi.org/10.1016/0092-8674(92)90593-2
                        

Identifiers

DOI: 10.1016/0092-8674(92)90593-2