A Large Kindred With 17q-Linked Breast and Ovarian Cancer: Genetic, Phenotypic, and Genealogical Analysis

David E. Goldgar; Patrick E. Fields; Cathryn M. Lewis; TV Tran; Lisa Cannon‐Albright; John H. Ward; Jeffrey Swensen; M.H. Skolnick

doi:10.1093/jnci/86.3.200

Abstract

Women with the BRCA1 mutation are at increased risk of developing breast and ovarian cancer. In our study population, the mutation appears to confer a lower risk of cancer at younger ages than found in previous studies. Continued interaction with family K2082 will be useful in longitudinal follow-up studies and in studies of the psychosocial implications of providing DNA diagnosis of BRCA1.

Keywords

Breast cancerOvarian cancerFamily historyCancerBiologyOncologyPopulationGeneticsGenetic counselingOdds ratioMale breast cancerGenetic linkageInternal medicineGynecologyGeneMedicine

Affiliated Institutions

University of Utah US

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Publication Info

Year: 1994
Type: article
Volume: 86
Issue: 3
Pages: 200-209
Citations: 99
Access: Closed

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APA Style

                            
                                
                                    David E. Goldgar, 
                                
                                    Patrick E. Fields, 
                                
                                    Cathryn M. Lewis
                                
                                et al.
                            
                            (1994). 
                            A Large Kindred With 17q-Linked Breast and Ovarian Cancer: Genetic, Phenotypic, and Genealogical Analysis. 
                            JNCI Journal of the National Cancer Institute
                            , 86
                            (3)
                            , 200-209.
                            https://doi.org/10.1093/jnci/86.3.200
                        

Identifiers

DOI: 10.1093/jnci/86.3.200