A Genetic Susceptibility Study of Lung Cancer Risk Potentially Associated with Polycyclic Aromatic Hydrocarbon Inhalation Exposure.

Abstract

To establish a genetic susceptibility assessment model of lung cancer risk potentially associated with polycyclic aromatic hydrocarbon (PAH) inhalation exposure among non-smokers in China, a total of 143 patients with lung adenocarcinoma and 143 cancer-free individuals were recruited. Sixty-eight genetic polymorphisms in 10 pathways related to PAH metabolism and tumorigenesis were selected and examined. It was observed that 3 genetic polymorphisms, along with 10 additional genetic polymorphisms via gene-gene interactions, significantly influenced lung cancer risk potentially associated with PAH inhalation exposure. Most polymorphisms were associated with PAH metabolism. According to the established genetic susceptibility score (GSS), lung cancer risk increased with a rise in the GSS level, thereby indicating a positive dose-response relationship.

Keywords

Lung cancerInhalationCarcinogenesisGenetic predispositionLung cancer susceptibilityCarcinogenMedicinePolymorphism (computer science)CancerOncologyGenotypeBiologyGeneticsInternal medicineSingle-nucleotide polymorphismGeneAnesthesia

Affiliated Institutions

Related Publications

The Genotype-Tissue Expression (GTEx) project.

John T. Lonsdale , Jeffrey Thomas , Mike Salvatore +97 more

Genome-wide association studies have identified thousands of loci for common diseases, but, for the majority of these, the mechanisms underlying disease susceptibility remain un...

2013 PubMed 9436 citations

A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants

Laura J. Scott , Karen L. Mohlke , Lori L. Bonnycastle +38 more

Identifying the genetic variants that increase the risk of type 2 diabetes (T2D) in humans has been a formidable challenge. Adopting a genome-wide association strategy, we genot...

2007 Science 2757 citations

Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels

Richa Saxena , Benjamin F. Voight , Valeriya Lyssenko +64 more

New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (...

2007 Science 2875 citations

A Common Variant in the <i>FTO</i> Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

Timothy M. Frayling , Nicholas J. Timpson , Michael N. Weedon +37 more

Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome...

2007 Science 4387 citations

‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*

George Davey Smith , Shah Ebrahim

Associations between modifiable exposures and disease seen in observational epidemiology are sometimes confounded and thus misleading, despite our best efforts to improve the de...

2003 International Journal of Epidemiology 6098 citations

Publication Info

Year: 2017
Type: article
Volume: 30
Issue: 10
Pages: 772-776
Citations: 3
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

A Genetic Susceptibility Study of Lung Cancer Risk Potentially Associated with Polycyclic Aromatic Hydrocarbon Inhalation Exposure.

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

OpenAlex

Cite This

APA Style

                            
                                
                                    Nan Lin, 
                                
                                    Mu Xl, 
                                
                                    Wang Gl
                                
                                et al.
                            
                            (2017). 
                            A Genetic Susceptibility Study of Lung Cancer Risk Potentially Associated with Polycyclic Aromatic Hydrocarbon Inhalation Exposure.. 
                            PubMed
                            , 30
                            (10)
                            , 772-776.
                            https://doi.org/10.3967/bes2017.104
                        

Identifiers

DOI: 10.3967/bes2017.104