A Comparison of Aspirin with Placebo in Patients Treated with Warfarin after Heart-Valve Replacement

Abstract

In patients with mechanical heart valves and high-risk patients with prosthetic tissue valves, the addition of aspirin to warfarin therapy reduced mortality, particularly mortality from vascular causes, together with major systemic embolism. Although there was some increase in bleeding, the risk of the combined treatment was more than offset by the considerable benefit.

Keywords

MedicineAspirinWarfarinPlaceboCardiologyInternal medicineHeart valve replacementHeart valveSurgeryAtrial fibrillationAlternative medicine

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Publication Info

Year: 1993
Type: article
Volume: 329
Issue: 8
Pages: 524-529
Citations: 548
Access: Closed

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APA Style

                            
                                
                                    Alexander G. G. Turpie, 
                                
                                    Michael Gent, 
                                
                                    Andreas Laupacis
                                
                                et al.
                            
                            (1993). 
                            A Comparison of Aspirin with Placebo in Patients Treated with Warfarin after Heart-Valve Replacement. 
                            New England Journal of Medicine
                            , 329
                            (8)
                            , 524-529.
                            https://doi.org/10.1056/nejm199308193290802
                        

Identifiers

DOI: 10.1056/nejm199308193290802