Keywords
Affiliated Institutions
Related Publications
Host Defense Mechanisms Triggered by Microbial Lipoproteins Through Toll-Like Receptors
The generation of cell-mediated immunity against many infectious pathogens involves the production of interleukin-12 (IL-12), a key signal of the innate immune system. Yet, for ...
Toll-like Receptors and the Control of Immunity
The study of innate immunity and its link to inflammation and host defense encompasses diverse areas of biology, ranging from genetics and biophysics to signal transduction and ...
Selective Roles for Toll-Like Receptor (TLR)2 and TLR4 in the Regulation of Neutrophil Activation and Life Span
Abstract Neutrophil responses to commercial LPS, a dual Toll-like receptor (TLR)2 and TLR4 activator, are regulated by TLR expression, but are amplified by contaminating monocyt...
IL-1 Receptor-Associated Kinase Modulates Host Responsiveness to Endotoxin
Abstract Endotoxin triggers many of the inflammatory, hemodynamic, and hematological derangements of Gram-negative septic shock. Recent genetic studies in mice have identified t...
Publication Info
- Year
- 2009
- Type
- review
- Volume
- 9
- Issue
- 8
- Pages
- 535-542
- Citations
- 689
- Access
- Closed
External Links
Social Impact
Social media, news, blog, policy document mentions
Citation Metrics
Cite This
Identifiers
- DOI
- 10.1038/nri2587